Výsledky vyhledávání pro dotaz cannabidiol:

Výsledky vyhledávání v sekci: blog

Whether acute or chronic - CBD relieves pain

Pain has many facesIn Germany, several million people live with chronic pain. The published numbers fluctuate. Ten to 25 percent of all Germans are exposed to regular pain - this corresponds to about eight to 20 million people. The statistics are therefore relatively inaccurate, because many pain patients do not go to the doctor with their suffering. Some are afraid of being laughed at, others have given up their fight because they have not gotten better after a long odyssey, yet others do not want to be permanently dependent on harmful medicines.The reasons for pain are so complex that they can not all be listed here. Medicine distinguishes between acute and chronic pain. Acute pain occurs suddenly and does not last very long. They are even useful because they signal to the body that something is wrong. Only then can the cause be identified and remedied. Chronic pain starts from a minimum of three to six months. They are no longer useful, but reduce the quality of life of the person affected. Frequently a chronic pain is caused by inflammation, tension, chronic illness or nerve damage. Even acute pain can be attributed to such causes. However, they are also often caused by injuries - both internal and external - or illnesses. If the cause of acute pain is not resolved quickly, there is a risk that acute pain will turn into chronic pain. In addition, strong, persistent pain sensitizes the body to further pain. The nerves react "exaggerated" in the episode, even if the cause of the initial pain has already been eliminated. Whether a pain becomes chronic or not depends, among other things, on the patient's disposition, family environment and mental state.CBD has been shown to be effective against pain in several studies. The Cannabinoid combats several causes of pain, rather than simply suppressing the feeling of pain, the latter also belongs to the repertoire of cannabidiol.CBD fights painIn tissue injury, CBD increases the concentration of anandamide in the body. This occurs through the interaction of the cannabinoid with the receptors of the human endocannabinoid system. Ananadamide is an endogenous endocannabinoid that is directly produced by the body, which directly affects the pain. The more anandamide in the organism or around the injured area, the better the pain relief. Ananadamide binds to the CB1 receptor (cannabinoid-binding receptor) and to the TRPV1 (a vanilloid) receptor, where it immediately combats the pain. This finding was made by scientists in China in 2010, when they performed experiments on mice.CBD helps against inflammationInflammation is often the cause of pain. Inflamed tissue increases the number of free radicals. These are dangerous for the body, as they have, among other things, the property of damaging cells. CBD is an antioxidant. In this function, it has a similar effect to vitamins A, C and E: they trap free radicals and thus render them harmless.In addition, CBD also has an anti-inflammatory effect per se. For example, a study by GWPharmaceuticals showed that CBD's properties can help fight inflammatory conditions in the intestinal tract, rheumatoid arthritis, diabetes and nausea.Researchers at the University of Mississippi found that CBD reduces oxidative stress and helps fight inflammation. Many other studies - such as those of the scientists of the National Institutes of Health in Bethesda (USA) - all led to the same result: Cannabidiol inhibits inflammation. In Bethesda, researchers also confirmed that CBD works effectively against neuropathic pain. Neuropathic pain is caused by dysfunction or nerve injury and can sometimes be very severe.CBD protects the nervesCannabidiol not only works against neuropathic pain, but has been shown to protect against the death of nerve cells - such as ischemic stroke, traumatic brain injury, multiple sclerosis, Huntington's disease and other chronic nervous disorders. The neuroprotective (nerve-protective) effect of CBD has been demonstrated both in living organisms and in test tubes. Apparently, anandamide and 2-AG (2-arachidonylglycerol, another endocannabinoid) play an important role. In a traumatic brain injury, substances are released that can lead to secondary brain damage. In 2002 Mechoulem et al. Annanadamide and 2-AG can inhibit the action of harmful substances. The endocannabinoid system together with the cannabinoids thus takes over a protective function here. As described above, CBD contributes to the proliferation of anandamide in the body and thus protects the nerves. CBD relaxes the body and works against stressWhile the cannabinoid THC works primarily on the psyche, CBD has a relaxing and regulating effect on the body. Cannabidiol has an anticonvulsant effect, which is why it is sometimes used to combat epilepsy. Tense muscles often cause pain such as back, head, menstrual and other pains. But also CBD has positive effects on the psyche: It can be used well for the treatment of depression and schizophrenia. But it also helps against insomnia and stress. Stress is the cause of many pain disorders. Anyone who manages to reduce his stress often notices an accompanying pain relief. CBD combats the causesIn addition to inflammation, stress, tension and nerve disorders, CBD can be used against many other diseases. To name just a few:sleep disordersBurnoutanxiety disordersepilepsyschizophreniaNausea and vomitingDependence on addictive substancesParkinsonCrohn's diseasearthritisdifferent cancersspasticityasthmaCBD not only combats the pain as symptoms of disease, but acts - as a variety of different studies have revealed - against the causes themselves. For this reason alone, cannabidiol is likely to be a healthy alternative to the synthetic drugs of the pharmaceutical giants in the long term. These usually only suppress the pain. For the fight against causes additional medicines must be taken. Most painkillers and most prescription medicines, which are not natural but man-made, are harmful to the liver and kidneys - especially if taken over a long period of time. CBD, on the other hand, does not have a great health-endangering side-effect because it comes from nature and is very similar to human cannabinoids. Unfortunately, CBD research is still in its infancy. There are first drugs based on CBD. Overall, however, the science knows too little about the exact modes of action of cannabidiol. Questions such as "What helps CBD?" Could already be clarified well. But on the "How exactly does CBD?" There are only insufficient results. In the future, CBD is likely to play a bigger role in medicine - the current state of knowledge suggests strongly. Even though there are only very few CBD drugs worldwide so far, every human being in this country has the opportunity to treat themselves with CBD oil and other CBD products. CBD is not prescription, therefore legally available. For safety, always consult a doctor who is familiar with CBD. Application and dosage vary from person to person. In principle, with a little patience, everyone will find the right dose for themselves, as long as he starts small and slowly increases it until the desired effect begins. This makes CBD a good supplement to conventional pain therapy. With a bit of luck, some pain patients can even replace their existing funds with CBD altogether. A trial (under medical supervision) would be worth it. Source: SOMMER, Kathrin. Ob akut oder chronisch – CBD lindert Schmerzen.  13 Apr 2018 Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/ob-akut-oder-chronisch-cbd-lindert-schmerzen/ Source photo: https://pixabay.com/cs/

Cannabis in the fight against epilepsy

CBD in anxiety disordersA number of case reports and studies show that CBD can reduce anxiety. In a study from 2017 by the University of Sao Paulo in Brazil, administration of CBD reduced anxiety in healthy individuals in a dose-dependent manner. The subjective anxiety was reduced with 300 mg CBD, but not with 100 and 900 mg CBD in a frightening situation (public speaking test). The mean dose was thus the most effective. The same researchers from Brazil investigated the effect of CBD on patients with generalized social anxiety disorder in a test that simulated speaking in a public situation. Three groups were compared: 12 healthy volunteers as a control group without medication; 12 patients with anxiety who received a single dose of CBD (600 mg) and 12 who received placebo. Previous treatment with CBD significantly reduced anxiety, mental disabilities and discomfort during speech. CBD also reduced the mental tension before the speech.At the Psychedelic Science Conference in San Francisco, April 19-24, 2017, a large case series of 136 patients was presented demonstrating that CBD, even in low doses of 40 to 50 mg, could be useful in treating anxiety.. Cannabis has both pro- and anti-convulsive effectsAt the congress of the DGN (German Society of Neurology) 2016 in Mannheim, however, Professor Heidrun Potschka warned against eating phytocannabinoids in an uncontrolled manner in order to combat epilepsy. According to experience reports of some epilepsy patients, they would often have had a seizure after eating a joint. In these cases, cannabis was thus proconvulsive, spasm-promoting. As a justification, she first gave the current state of science: The cannabinoid-binding receptor CB1, which is part of the ECS, inhibits overactive synapses via a feedback loop. CB1 is presynaptic. If the overactive synapses release too many neurotransmitters, the postsynapse causes the release of endocannabinoids, which bind to the CB1 receptor and thus restrict the production of neurotransmitters. This process happens in both inhibitory and excitatory connections. Potschka believes that it would therefore depend on the current state of the brain whether the CB1 agonist THC would be more spasm-promoting or antispasmodic. Exactly to this topic is not yet known. It should not be left unmentioned that Potschka is employed at the Pharmacological Institute of the LMU Munich and may well represent her opinion from a pharmacological point of view and with corresponding interests. The cannabis plant not only has THC as an active ingredient, but also many other compounds that can have a positive or negative effect on convulsions. For the most part, science is still in the dark. Currently, in epilepsy research, the focus is not primarily on THC but on its antagonist, cannabidiol. There were consistently positive results with CBD. Cannabis: Studies show positive effects in epilepsyVarious studies worldwide - both human and animal - have now shown that the intake of cannabinoids counteract the onset of epileptic seizures. In addition, it has been shown that it is not only acute epileptic seizures that can be reduced by the administration of cannabinoids, but that the herbal active ingredients can also provide effective protection against the development of epilepsy. In addition, cannabinoids are neuroprotective. That means they protect the nerves. In addition, they are likely to interfere with excessive release of glutamate, which can damage the brain and be released during an epileptic seizure. Especially CBD is currently on everyone's lips when it comes to effective drugs for epilepsy - even if THC can demonstrably prevent seizures. The side effects of CBD are very manageable. Especially drowsiness and loss of appetite should be mentioned here. Another positive side-effect of CBD in the case of epilepsy is that it may potentiate the effects of conventional epilepsy drugs such as carbamazepine, diazepam, felbamate, gabapentin, phenobarbital, topiramate and valproic acid. The results of a study strongly suggest this. However, in-depth knowledge is still pending. It would be conceivable in the future that CBD could be used in drug form specifically for such reinforcement. Currently, cannabidiol is mainly as so-called "orphan drug", so approved as an orphan drug, and only for a limited number of epilepsy forms, such as: Dravet syndrome, Lennox-Gastaut syndrome and tuberous sclerosis. Orphan drugs are subject to strong regulatory restrictions and may only be marketed for very rare diseases. Since CBD is available legally and without a prescription, as long as it is not offered in the form of a drug, but as a kind of dietary supplement, a large number of epilepsy patients who have treated themselves with cannabidiol report positive effects of the herbal active ingredient. The incidence of seizures has decreased in many cases with the use of CBD, which is consistent with findings from other studies on CBD and epilepsy. Outlook: Cannabinoids as an alternative medication for epilepsyDespite less critical voices in part opposing the use of cannabinoids in the treatment of epilepsy, science continues to provide hope-rich insights into cannabis and epilepsy. The first step towards the approval of drugs containing cannabinoids has already been made. Given the current research efforts, a considerable number of additional medicines may well be expected in the not too distant future. Whether the cannabinoids are then synthetically produced or taken from nature remains to be seen. However, it is clear that phytocannabinoids, which are not produced in the laboratory, are better tolerated than man-made compounds. With the active ingredients of the cannabis plant might even make a breakthrough in epilepsy treatment. It is - as so often - not least a question of the various interests that meet in the health system, whether and in what form or with what emphasis and success ultimately the affected people help with new drugs is offered. In the meantime, there is still a lot of room for self-help. The legally available CBD - whether in the form of oil, capsules, tablets or tinctures - is (still) freely available, so that every epilepsy patient can supplement his treatment. Of course, such proprietary therapies should always consult a knowledgeable physician and be mindful of the good (bio) quality of the CBD product. Anyone who does so, should be justified with a little patience justified hope for improvement. Source: SOMMER, Kathrin. Cannabis im Kampf gegen Epilepsie 29 march 2018. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cannabis-im-kampf-gegen-epilepsie Source photo: https://pixabay.com/cs/   

Phytocannabinoids - purely vegetable

Renewable medicine"Phyto" comes from the Greek and means "plant". Cannabinoids are produced in the body, in some plants and also in some chemistry laboratories. The hot "endogenous cannabinoids" produced in the body, from the chemical laboratory "synthetic cannabinoids". There are also semisynthetic or artificial cannabinoids, which find their source material in the plants. The term phytocannabinoids explains that they are cannabinoids of plant origin that have not been artificially altered in their molecular structure. There are well over 100 phytocannabinoids in cannabis alone. In other plants, these are not or only in small numbers and low concentration contained. Who would like to win phytocannabinoids, would therefore decide for the plant genus cannabis. No proven deathsAt a lethal dose death occurs. For drugs of medicine, the lethal dose is determined in order to be able to deal with patients safer. With other substances, too, this lethal dose is being sought in order to be able to better assess it. Depending on the research, THC, one of the most common phytocannabinoids, would require hundreds of grams or even 1,500 pounds of cannabis to reach this lethal dose. These quantities would have to be absorbed within a very short time, which is hardly technically possible. It is conceivable that other phytocannabinoids with far lower concentrations could trigger such a lethal dose. They are also contained in cannabis at a lower concentration. However, the fact is that there is still no valid report on a cannabis death. There are reports of people who allegedly died of cannabis. Some were simply found no causes of death, but traces of THC, which then this "the cause of death" was. However, assumptions or insinuations are not valid evidence. With synthetic cannabinoids, even small amounts of active substance can trigger a lethal dose or leave lasting damage, which means that they should be regarded as a substance class with much greater care. Unfortunately, there are now hundreds, perhaps thousands, of people worldwide who have already died of synthetic cannabinoids. With a regulated cannabis market that allows adults to buy or grow their cannabis in good quality at acceptable prices, hardly any synthetic cannabinoids would be used. The research on phytocannabinoidsEven though more than 100 phytocannabinoids have been found in cannabis, research is still in its infancy. Just cannabidiol and tetrahydrocannabinol are reasonably well researched. However, many cannabinoids that may have high medical potential have been virtually undetected. There are e.g. Phytocannabinoids in the hemp plant, which are found in the immature flowers or immature plants, but no longer in the mature. These cannabinoids can also have a very high medical potential. Since plants are currently allowed to mature for cannabis production, the cannabinoids on immature plants have not been much researched. But many other phytocannabinoids, which are not always or only in trace amounts in cannabis, have not received much attention yet. In many cases, it is assumed that only the female cannabis plant forms active substances and can be used medically. That's not true, even the male or hermaphrodite cannabis plant forms phytocannabinoids and other active ingredients. However, it forms smaller amounts of these drugs. But maybe there are active ingredients in male cannabis plants that are not found in females? If even the cannabis plant's roots, stems and leaves contain active ingredients and can be used medicinally independently of the cannabis flowers, cannabinoid research certainly does not address the issues. Source: BRUNGERT, Robert. Phytocannabinoide – rein pflanzlich. 23 march 2018,. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/phytocannabinoide-rein-pflanzlich/ Source photo: https://pixabay.com/cs/

CBD in cosmetics - how well does cannabidiol affect our skin?

the biggest appeal features - no wonder we're ready to invest a lot in effective skin care products. Care products that contain CBD extracts such as CBD oil are currently emerging as a new trend in the cosmetics market. Are you just a marketing gimmick? On the contrary, medical studies hope that cannabidiol could help with skin problems: Which cosmetics with CBD are there?Almost the entire spectrum of personal care products you will also get today with CBD offset: from shampoo, on the lip balm to creams and ointments. The latter are advantageous because they are not washed out or washed off like soap, but let the valuable ingredients of the contained CBD extract penetrate into the skin. In addition to cannabidiol, ointments and creams naturally also contain ingredients which give the respective product its consistency and scent. Make sure that natural fats such as shea butter, mango butter or cocoa butter are used. They moisturize the skin and have a moisturizing effect. As fragrances, producers of high-quality products use natural essential oils, which in turn supply valuable terpenes. Quality products can be recognized by the fact that a CBD full spectrum extract forms the basis and neither artificial preservatives nor fragrances are processed. Vitamin E, on the other hand, is a natural preservative in CBD cosmetics that protects both our products and our skin from oxidation damage. Is CBD absorbed through the skin?Like all cannabinoids, CBD is a lipophilic substance that dissolves well in oils and fats. Therefore, it also combines with the human skin fat and is absorbed through the epidermis in the metabolism. Studies show that skin gives CBD 10 times more permeability than THC.  But can CBD also influence the organism through this passage? Preclinical experiments with animals show that CBD also has high efficacy via the transdermal route. For example, a gel containing cannabidiol in arthritic rats reduced joint swelling and pain and improved their mobility. In another experiment, CBD mitigated an addictive behavior induced by stress as an ointment in the experimental animals.  Also, pharmaceutical companies want to use the transdermal uptake of CBD in their products in the future: The Canadian manufacturer Cannabis Science announced to develop a CBD patch that will help patients with fibromyalgia and neuropathic pain in the future. How does CBD affect the skin? Because CBD is anti-inflammatory and immunoregulatory, it could primarily help people who suffer from inflammatory skin conditions. Researchers see above all possibilities in the treatment of acne. Because of the activation of the vanilloid receptor type 4 CBD demonstrably inhibits the activity of the sebaceous cells in the sebaceous glands, called sebocytes.  In addition, it also has an inhibitory effect on cells of the epidermis, which are responsible for the formation of the horny layer. This could help people with psoriasis, whose complaints are caused by excessive activity of horn-forming keratinocytes. Finally, patients with severe skin diseases already benefit from CBD in practice. Case reports of sufferers of rare skin conditions, such as epidermolysis bullosa, show that their symptoms significantly decreased with cannabidiol therapy. Itching, sore and scarring, blisters and the limitations of mobility decreased so much that some patients could even do without opioid analgesics.  Source: CBD in Kosmetik – wie gut wirkt Cannabidiol auf unsere Haut? Apr 25,2019. Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-kosmetik Source photo: https://pixabay.com/cs/

CBD and the Immune System - Can Cannabidiol Support the Immune System?

Colds, herpes, allergies - many complaints in everyday life, we lead back to the fact that our immune system does not work optimally. Sometimes it seems to let us down, sometimes it reacts stronger than it should. As scientific studies show, CBD could interfere with oil regulation: How does our immune system work?Our organism comes into daily contact with bacteria, viruses and environmental toxins. If foreign cells enter the body, we need an instance that distinguishes friend from enemy. This task is done by the human immune system. It's not a conduit network like our bloodstream and our nerve cells, but rather a communication network that involves cells of different types. They provide each other with information about potentially threatening substances and the state of health of tissues and organs. If a substance enters the system that is identified as hostile, certain signal substances (cytokines) initially trigger an inflammatory process. This alerts other immune cells, such as our leukocytes or killer cells. They have the ability to destroy and consume pathogens. Even infected body cells are destroyed by the defense cells. As efficient as it sounds - the human immune system is not always working optimally. Allergies arise when the immune system overreacts to certain plant substances. In contrast, autoimmune diseases develop when defense cells falsely attack their own body cells. Immune system and cannabinoids - where is the connection?Receptors, so "docking" for cannabinoids are located on many cells of the immune system. T cells, neutrophil granocytes, monocytes, NK cells and B cells have CB2 receptors to which cannabinoids can bind. If they do so, they attract other immune cells to a damaged site in the organism through chemical signals. At the same time, however, cannabinoids are also responsible for balancing the immune system and avoiding overreactions. This task is usually done by our endogenous cannabinoids, the endocannabinoids. However, if there are deficits or imbalances, herbal cannabinoids such as CBD can be helpful. The optimal function of our immune system depends directly on the balance of our endocannabinoid system. If the CB1 receptors in our body are strongly inhibited, the immune system may be impaired in its function. If the organism does not have endocannabinoids such as anandamide and 2-AG, it may lead to diseases such as irritable bowel, fibromyalgia or migraine. Scientists believe that supplementing herbal cannabinoids in these cases can promote good health. Source: CBD und das Immunsystem – kann Cannabidiol die Immunabwehr unterstützen? Apr 29,2019. Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-und-das-immunsystem Source photo: https://pixabay.com/cs/

CBD in allergies - can cannabidiol soothe the immune system?

Some of them are happy when trees and flowers are blooming in spring, while others would rather escape to the North Pole. In particular, hay fever sufferers can hardly enjoy the warm season, because they bring along with the pollen Schniefnasen, watery eyes and sneezing attacks. But also food allergies; House dust allergies and incompatibilities with chemicals make everyday life difficult for those affected. What happens in the body during allergies, such as CBD oil could increase the well-being of allergy sufferers, you will find out here: What are allergies?In an allergy, the human organism reacts to individual substances of its environment (allergens) with a strong immune response. In this case, pro-inflammatory substances such as e.g. Released histamine that cause typical discomfort. The physical symptoms then express themselves in:red and irritated eyesirritated nasal mucosahay feverSneezeto coughallergic asthmadigestive problemsSkin irritation and rashEczema and eczemaFor example, allergens are taken via the respiratory tract, as is the case with widespread hay fever. According to recent surveys, about 14.5 percent of all Germans suffer from respiratory ailments during their heyday. In addition, allergens can also enter the body through food or through direct skin contact. What is the usual therapy for allergies?Here are two approaches: The first is based on drugs that reduce the production of the inflammatory histamine in the body, so-called antihistamines. These preparations are effective and are available over the counter. However, they are sometimes associated with unpleasant side effects, especially with severe fatigue. In addition, there is the possibility of hyposensitization for allergy sufferers. In this case, the person concerned receives low-dose injections of the corresponding allergen, in order to slowly get the body used to the substance. How does CBD affect our immune system? The human endocannabinoid system and the immune system are closely related. After all, CB2 receptors to which cannabinode can bind are located on the important cells of the immune system, for example the T cells. Here, cannabinoids can regulate how many pro-inflammatory signaling substances are released during an immune response. Researchers in the animal model of asthma demonstrated that this regulatory effect can have a beneficial effect on allergic reactions. Treatment with CBD was able to significantly reduce the pro-inflammatory signaling, various interleukins and tumor necrosis factor alpha in the lung tissue of the experimental animals. The authors of the study are in favor of CBD as a potential future therapeutic for the inflammatory processes in asthma. Surveys in dermatology, however, see opportunities in CBD to treat atopic dermatitis and contact allergies. Finally, scientists in the animal model of arthritis have observed that cannabidiol can also regulate autoimmune responses by reducing the presence of proinflammatory signaling in the synovial fluid.  Which CBD products are suitable for an allergy?Dietary supplements with CBD are freely available in Germany and do not bring the risk of side effects. Unlike with the use of antihistamines, allergy sufferers do not have to worry about drowsiness. It is known from scientific experiments that CBD is absorbed well via the oral mucosa and via the transdermal route. In principle, allergy sufferers can therefore use CBD oil or CBD balm. When products are applied to the skin, it is important that there are no ingredients that can cause allergies. Ideal are CBD balms, which contain only natural fats such as shea butter or mango butter and do without chemical preservatives and fragrances. Even less risk of allergies exists in CBD oils based on MCT oils. They are dripped under the tongue on the oral mucosa to ensure optimal absorption of the ingredients in the organism. Beginners should begin with a 5 to 10 percent CBD oil picking and a dosage of 3 drops twice a day. Source: CBD bei Allergien – kann Cannabidiol das Immunsystem beruhigen?  May 2, 2019. Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-bei-allergien-oder-heuschnupfen Source photo: https://pixabay.com/cs/

Does CBD help stomach and intestines? Cannabidiol and the digestive tract

A good gut feeling is not only important in the figurative sense: The fact that the digestive tract works smoothly is essential for general well-being. But there is a problem here: it is estimated that 29 percent of the European population experience recurring indigestion; A total of 400,000 patients in Germany suffer from inflammatory bowel disease. Could CBD oil help alleviate the symptoms here? Below you will learn how the endocannabinoid system interacts with the digestive tract and what recent studies on CBD have found in bowel disease: What makes a healthy digestive system?The health of our intestinal tract is not only our business, but also that of trillions of microorganisms. Their job is to help digestion, neutralize potential toxins, make vitamins and communicate with the immune system. If bacterial colonization in the intestine is disturbed by pathological conditions, chronic intestinal inflammation and even mental illness can be the result. Animal experiments have already shown how the change in the intestinal flora in mice results in increased anxiety and a tendency to depression. Also in patients with a post-traumatic stress disorder, changes were detected in the occurrence of special intestinal bacteria. No wonder then that our intestinal tract is also referred to by some scientists as the "gut brain". A gut feeling would therefore not be a vague feeling, but may be the result of the collective intelligence of trillions of intestinal bacteria. How do cannabinoids affect the intestine?The human endocannabinoid system also extends to our digestive organs. CB1 receptors are located in the stomach and intestine, where they allow (endo) cannabinoids to control appetite and saturation. In addition, they affect motility, i. the movements that maneuver our food through the digestive tract. Finally, the anti-inflammatory potential of some cannabinoids could have a positive effect on the intestinal mucosa and correlate with a healthy intestinal flora: In which intestinal diseases could CBD support well-being?A well-known chronic intestinal disease is irritable bowel syndrome. Physicians are still uncertain about his cause - but his symptoms severely affect the quality of life of those affected: diarrhea, flatulence, cramps and constipation are the result. Stress, intolerance to certain foods or taking hormone supplements such as the "pill" can cause relapses. Scientists are currently working on a theory that explains chronic pain in irritable bowel syndrome, which can hardly be attributed to external factors, by a lack of endocannabinoids (Clinical Endocannabinoid Deficiency Syndrome). [2] Here, an intake of herbal cannabinoids such as CBD could possibly have a positive effect and reduce painful discomfort. This thesis is supported by numerous reports of irritable bowel patients, whose quality of life CBD could increase. CBD and inflammatory bowel disease and CBDIn inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, there are inflammations of the intestinal tract, which cause bumpy severe discomfort. Doctors suspect the triggers in an autoimmune reaction. The fact that cannabis preparations can alleviate the symptoms is well known. [3] In addition, a 2011 study examined the mechanisms by which CBD, as a single substance, could exert a positive influence on inflammatory processes in the gut: it has been shown to control the activation of enteric glial cells. In turn, these cells increasingly release growth factors and inflammatory signaling substances (cytokines). In excess they can cause inflammation. The modulating capabilities of CBD could mitigate these processes.  Source: Hilft CBD Magen und Darm? Cannabidiol und der Verdauungstrakt. Apr,22 2019. Dostupné z: https://fivebloom.de/blogs/cbd-news/hilft-cbd-magen-und-darm Source photo: https://pixabay.com/cs/

Regular pain: CBD helps

CBD relaxes and relieves crampsWhile most of the average 28-day cycle is relatively calm and normal, the uterine muscles begin to contract just before the menstrual period. These contractions interrupt blood flow in the abdomen. It is precisely this interruption that causes more pain in one woman and less pain in the other. Happy are those who do not suffer at all. In some girls and women, however, the pain is so unbearable that they therefore even fail in everyday life, so must report to the employer sick or can not go to sports. In Germany, therefore, many patients resort to analgesics such as ibuprofen or acetaminophen. Others prefer to take antispasmodic drugs from the pharmacy. However, this is more of a permanent solution with two eyes closed, as this type of medication has negative effects on the body. For example, they strain the kidneys when taken regularly. Some pain sufferers now stick electrodes instead to the skin. By light surges, the muscles should relax and provide relief. While some swear by it, others complain about the annoying feeling of having to walk around the bikini area with electrode stickers, where one can not move quite as freely during the days anyway. Often, young women are prescribed the pill to prevent the unpleasant side effects of menstruation. However, it is artificially intervened in the hormone balance to prevent ovulation. The cannabinoid CBD is according to the current state of research free of side effects. It naturally acts on the human endocannabinoid system. This expands throughout the body and even produces various cannabinoids to keep the immune system intact. However, this system is prone to disorders such as illness and stress - the latter is also caused by pain. By administering CBD in the form of oil or capsules, the inner balance can be restored. CBD has a relaxing, anti-spasmodic and anti-inflammatory effect. For menstrual problems, it is therefore a good treatment option. Since it contains virtually no THC and therefore does not have an intoxicating effect, women who suffer from period pain can obtain CBD legally and without a prescription. Different types of menstrual pain and their causes The female cycle is determined by different hormones. The goal is to prepare the body for possible reproduction. Therefore, the uterine lining builds up in the first half of the cycle. It is well supplied with blood and thick or short: ready for the implantation of the fertilized egg. However, if there is no fertilization and thus no pregnancy, the mucosa dissolves in the second half of the cycle after ovulation from the uterus. The excretion takes place during the period. After the menstrual period, the circulation starts again, so the menstrual pain occurs every month again. Generally, a distinction is made between primary and secondary menstrual pain. The primary menstrual pain falls into the category of "natural", which is pain that occurs during the menstrual period, without any pathological change in the female body. The women who suffer from primary periodic pain have been fighting this problem since puberty. Secondary menstrual pain primarily affects older women and is mostly due to illness. Changes in the female reproductive system often cause painful days. Such changes include, for example, endometriosis (small, benign growths in the abdomen), uterine infections, and ovarian cysts. Frequently by these diseases not only the intensity of bleeding increases, but also pain. In general, there are various factors, besides malformations or diseases, which can aggravate menstrual pain. These include a low body weight, an irregular or longer than average cycle, the consumption of alcohol and nicotine, the prevention of pregnancy with the help of the spiral, stress or other psychological causes. Symptoms of menstrual painMany readers know her too well - the typical symptoms of menstrual cramps: cramping and tearing in the abdomen. The pain can follow at short intervals, be regular or prolonged, and can be up to the back. Often, digestion is also affected during the period, so some women suffer from diarrhea or nausea. Even headaches can be part of the discomfort. Anyone who is in constant pain and uncomfortable will eventually get into a bad mood. In addition, fatigue, fatigue and lower concentration or performance are added to this. Many women would therefore just like to lie in the hot tub or with a hot water bottle on the stomach on the couch and wait for the first two, so the worst days, pass as quickly as possible. Different forms of CBD for menstrual pain Not only hot baths and hot water bottles relax the cramped uterus, but also sex. But after a suitable partner is not always and everywhere available and women can not spend hours in the bathroom, it makes sense to relax the body in other ways. CBD has anti-spasmodic properties, reduces stress and relaxes, and therefore relieves menstrual pain. Already Queen Victoria's doctor, Sir Joshua Reynolds, knew about the beneficial effects of the cannabis plant and ordered the majesty a suitable cannabis tincture against her menstrual pain. Women in Asia and Africa have also been relying on natural pain relief from cannabis products for centuries. In our society, the use and research of cannabinoids has long been neglected by the illegalization of the hemp plant. However, countries such as the US and Canada are now turning around and the research and production of various cannabis products is evidently progressing inexorably. Europe is slowly catching up. The US actress Whoopi Goldberg has recognized the trend and together with the food manufacturer Maya Elisabeth sells medical cannabis products under the name "whoopi & maya", which are tailored to women with regular pains. In addition to cannabis tinctures and ointments, the ladies also offer a bath additive and chocolate with the corresponding active ingredients. In liberal California and the US state of Colorado, pain-stricken women enjoy the so-called cannabis tampons, which are marketed under the name of Foria Relief. Actually, this product is not really a tampon, but a suppository, which is introduced before using a tampon. Within 15 to 30 minutes, the suppository dissolves, so that the active ingredients are absorbed by the vaginal mucosa. In Germany, the suppositories are not yet available because they contain besides ten milligrams of legal CBD also 60 milligrams of psychoactive THC. Many women reported having a relaxing effect and pain relief after about eight minutes. The THC can be detected by the usual drug tests in the body. Medically sound studies on Foria Relief are pending. We also have medical cannabis products on prescription from the pharmacy. These are mainly used in palliative medicine. In menstrual pain, it would be extremely difficult to find a doctor and a health insurance company who would participate in a prescription. The legal alternative is CBD. In the form of oil, you can either take cannabidiol orally or drip one or two drops on a tampon to make it easier to get it right where it's needed. Instructions for buying CBD productsTo minimize the unwanted ingestion of any pollutants, attention should be paid to the bio-seal when purchasing CBD products. Oils should contain at least 99 percent pure CBD. When manufacturing, it is important to keep an eye on ensuring that the products are as close as possible to the GMP (Good Manufacturing Practice for Medicines) and ISO standards so that they are of a certain quality. Court decision regarding cannabis use against menstrual painAt this point the readers should not be deprived of the court order of 4 January 2017 from Baden-Württemberg: A woman who regularly consumed cannabis for six to seven days a month - the intoxicating THC variant, not the pure CBD - wanted to deprive the driving license authority of their driving license. In an urgent procedure, however, the Freiburg administrative court ruled that the woman was allowed to keep her driver's license for the time being. The reasoning was that the person concerned would firstly have not combined consumption and driving, and secondly, they would not take cannabis regularly. Even if the consumption was monthly over several days, the woman did not take THC-containing products on the menstruation-free days and therefore did not fulfill the conditions necessary for a driving license withdrawal.The decision may be understood as a positive sign in the direction of cannabis for pain relief. Source: SOMMER, Kathryn. Regelschmerzen: CBD schafft Abhilfe. 21 Feb, 2018 Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/regelschmerzen-cbd-schafft-abhilfe/ Source photo: https://pixabay.com/cs/

CBD as a versatile remedy in sports

But not only in medicine promises CBD new treatment options. The properties of cannabidiol can be used, for example, for faster regeneration or performance enhancement in sport. Prominent examples from the US could establish CBD as a supplement and remedy in sport. What is cannabidiol?Cannabidiol (CBD) is one of over several hundred cannabinoids in the hemp plant and the second best known besides THC. Especially medical users became aware of the therapeutic properties of CBD. CBD has no psychoactive effect and can even mitigate the high produced by THC. Nowadays you can find varieties on the market, which were bred especially for their high CBD content and more and more seed banks jump on the CBD train. With their Super Silver Haze CBD, Greenhouse Seed Company released a popular CBD version of the popular classic with a THC: CBD ratio of 1: 1. In addition, the breeders of CBD crew inspired many patients with their variety CBD Therapy, which has a THC: CBD ratio of 1:20 (!) And thus has a particularly high medical potential. However, CBD can not only be consumed in the form of flowers. Many manufacturers offer CBD oils in different dosages or creams with CBD from organically grown hemp plants. A very pure form of cannabinoid is CBD crystals, a white powder produced by extraction with CO2.  CBD in sportsAs already mentioned, CBD has a very high medical potential, which can also be used profitably in sport. Many hobby and competitive athletes report that CBD increases their focus when taken before a training session and thus they can achieve better performance. The stress-relieving effect of CBD can increase mental performance, thus making exercises or units more accurate. This reduces the risk of injury and over-exertion. Excessive physical stress often causes muscle pain or painful muscle tension. CBD binds, inter alia, to the TRPV-1 receptor, which is responsible for pain perception, inflammation and the regulation of temperature. As a result, CBD can relieve pain such as muscle soreness or tension to get fit for the next session. In addition, cannabidiol stimulates the adenosine receptor and therefore plays an important role in cardiovascular function and blood circulation. Thus, we have arrived at another huge advantage of CBD in the application in the sport. Namely the faster regeneration. The relaxing effect can serve as Muskelrelachsans and shorten the recovery phase between training sessions. By stimulating the blood flow, the muscles are supplied with more oxygen again and can be more stressed or recover better. Even nausea after a hard workout can be treated with cannabidiol. Prominent examples from the USAAbove all, professional top athletes are under constant stress from training and competitions and expose their bodies to extreme stress. Not infrequently a serious injury is the result of a auspicious career. Not to mention the huge sums of money used in professional sports. In the American Fottballliga NFL one has therefore always resorted to strong painkillers such as Percocet and Vicodin, to suppress the pain of an injury. Not infrequently complain players after taking on stomach ache, nausea and / or fatigue. Not to mention the danger of dependence, which is almost inevitable with such strong resources and regular intake. Former quarterback Jake Plummer is now campaigning for allowable use of CBD for recreational purposes in the NFL. With the analgesic and anti-inflammatory effect cannabidiol is the natural alternative to strong (prescription) analgesics and no side effects or the risk to become dependent. According to a 2011 Washington University study in St. Louis, 52% of retired NFL players resorted to opiates during their careers. This means more than half of the pharmaceutical industry's former professionals fall victim in the US. It is estimated that at least 50% of NFL active players defend themselves against the abuse of potent painkillers and treat themselves with some form of cannabis as a medicine. In the American Basketball League (NBA), it even estimated an 80%. At least some of the players seem to have understood the problem and are switching to the natural alternative. Also in other sports the positive effects of CBD seem to have spread. Last year, UFC fighter Nate Diaz appeared at a press conference after a fight with a vaporizer. When asked about this, Diaz explained that it is cannabidiol and continues: "It helps against pain and inflammation and supports the healing process. It makes your life a better place. " Application of CBDCBD can not only be consumed in the form of flowers. There are CBD oils with different concentrations, CBD creams for application on the skin or the already mentioned CBD crystals. Either way, CBD not only has the potential for professional athletes to relieve pain after hard physical exertion and is THE natural alternative to strong painkillers that have a lot of side effects and the risk of dependency. It remains to be seen what will emerge in the future in this area, but with advancing useful research and prominent representatives, this wonderful plant may soon be used in sport as an effective means of relieving pain and increasing performance. Source: BOEDEFELD, Christian. CBD als vielseitig einsetzbares Heilmittel im Sport.. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cbd-als-vielseitig-einsetzbares-heilmittel-im-sport/ Source photo: https://pixabay.com/cs/

Cannabis for autistic children

MODI'IN IN ISRAEL - Noa Shulman, 17 years old, is one of those children who have already attracted attention as an ego-centrist in kindergarten and at school. She lives seemingly completely withdrawn in her very own universe and has a hard time communicating with the outside world: Noa suffers from autism.When Noa comes home from school, she is spoon fed by her mother, Yael - sweet potato puree mixed with a cannabis-derived oil. Noa is part of the first clinical trial in the world to demonstrate the benefits of medical marijuana in the treatment of adolescents with autism. The positive effect should be provenThis study could be the breakthrough, helping millions of sufferers and their parents help and alleviate symptoms. The study started in January of this year at the Shaare Zedek Medical Center in Jerusalem. 120 children and young adults aged 5 to 29 with mild and severe autistic features are participating in the study, which will end in 2018. The group is expected to take cannabis daily, planned twice twelve weeks, interrupted by a one-month break. Nobody smokes a joint though. An extract of cannabidiol, which is mixed in the ratio of 20 to 1 with olive oil, is administered.There has long been evidence that cannabidiol (CBD) helps children and adolescents such as Noa, as has no other treatment or medication. This study should prove that. In 1992, Israel was the first country in the world to approve the use of medical marijuana. Like Canada and the Netherlands, this medical program is supported by the state and paid by the government. Tamir Gedo, CEO of "Breath of Life Pharma *," who made the cannabis oil for study participants, said that a mother told him, "My child is talking uninterruptedly. ... He never said a word before. And he is twelve years old. "Of course, there are also external concerns about the study. Pediatricians from America fear damage to the participants' brains due to the early intake of cannabis. But Gedo sees it differently, other drugs such as opioids hurt the children much more. "These families have no other hope." In Germany, the number of autistic people is estimated at around 35,000. * "Breath of Life Pharma" (BOL Pharma) is led by an experienced team of medical experts, scientists and cannabis business experts who have vast experience in clinical trials, precision farming, agriculture and marketing of pharmaceutical and healthcare products. BOL Pharma also owns the largest cannabis plantation in Israel, which is used for medical purposes. Her specialties include immunology (multiple sclerosis, fibromyalgia), pain therapy (chronic pain, neurological pain), gastrointestinal diseases (IBD), rheumatology (osteoarthritis), dermatology (psoriasis, atopic dermatitis). Source: NESTLER, Julia. Cannabis für autistische Kinder. 5 Jun 2017. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/cannabis-fuer-autistische-kinder/ Source photo: https://pixabay.com/cs/

What is cannabidiol?

Cannabidiol (abbreviated: CBD) is the second most abundant cannabinoid in hemp, after the main active ingredient THC. It therefore belongs to the phytocannabinoids and occurs mainly in the hemp with an amount of up to 2% in the flowers.Cannabis indica-dominant strains have a higher CBD content than strains dominated by cannabis sativa.CBD taken alone does not cause any intoxication - it is not essentially psychotropic (with the exception of the slightly sedating effect) - and no relevant (psychic) ​​side effects.The individual effects of the substance, as well as those of other cannabinoids, have not been fully explored. So there is room for discovery of other medical effects. The effect in isolated form is also to be considered differently than in combination with many other substances of the cannabis plant (for example over 100 cannabinoids alone, as well as flavonoids, terpenes, terpenoids).CBD mediates its effects via both the CB1 and CB2 receptors. These are receptors of the endocannabinoid system (ECS), are activated or inhibited by the body's own cannabinoids (endocannabinoids) and influence many physiological processes; Among other things, the EC system has an involvement in diseases of the metabolism, disorders of the nervous system and the psyche, pain and inflammatory processes, cancers and diseases of the gastrointestinal tract, to name just a few examples.CBD can be understood as mediating the effects of THC, as it enhances the analgesic, mind-altering and euphoric properties of THC; On the other hand, it acts as an antagonist by inhibiting the increase in appetite caused by THC, increasing the heart rate as well as any unpleasant psychological effects (increased anxiety, anxiety, paranoia).For a long time, cannabis breeders were primarily concerned with keeping the CBD content as low as possible in order to achieve a better "high". So it is in many popular cannabis strains at less than one percent. Meanwhile, however, there is a clear trend of medical use in the direction of high-CBD strains, so CBD-rich varieties, which come up with a significant medical potential, without really psychedelic effect.The effect here is more towards plättend, body-accentuated and pleasantly soothing on the psyche. Therefore, CBD-rich cannabis strains (e.g., in ratio (CBD-THC) 1: 1 or even 2: 1) are ideally suited for treatment of, for example, muscle spasms, sleep disorders, and anxiety.CBD is not regulated in Germany, Austria and Switzerland and is absolutely legal in its pure form. Source: FÖRSTER, Hendrik. Was ist Cannabidiol? 13 Jan, 2015. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/was-ist-cannabidiol/ Source photo: https://pixabay.com/cs/ 

CBD (cannabidiol) in ancient Egypt

Often, cannabidiol is reported as a new phenomenon. Due to the growing cultural acceptance of the hemp plant, CBD has experienced a tremendous increase in popularity over the last decade. In fact, the cannabinoid was used much earlier by one of the Earth's oldest civilizations - Ancient Egypt.Cannabidiol - a wonder drug?CBD is a phytocannabinoid - a natural, plant-produced compound. In this case, the compound comes from the hemp plant. In 1964, the Israeli scientist Dr. Raphael Mechoulam the psychoactive substance THC. The now 88-year-old Professor of Pharmaceutical Chemistry and Natural Products at the Hebrew University of Jerusalem is recognized as one of the most important researchers in cannabis research by discovering the most important ingredients of the cannabis plant. In addition, it has played a significant role in Israel's pioneering role in researching the therapeutic properties of cannabinoids and in medical applications.For example, by altering the concentration of neurotransmitters in the brain, the effect of cannabidiol can affect pain, contribute to relaxation, or help with sleep problems. There are reports of the anti-inflammatory effect of topical treatment of inflammatory skin diseases such as atopic dermatitis.originCBD is made from the hemp plant that has been cultivated by humans for thousands of years for its versatile fibers, seeds and flowers. The oldest finds come from China around 2800 BC. Chr., Where one manufactured ropes from hemp fibers.Presumably, however, the plant has been used earlier and there is evidence of its use in traditional Chinese medicine, which continues to decline. Over time, the hemp plant in the paper, textile, food and medical industries became more important worldwide, until the cultivation of hemp was taxed so heavily in the US in 1937 with the Marijuana Tax Act that it was barely affordable for farmers more rewarded.Holy hempSeshat was an ancient Egyptian deity of wisdom, writing and knowledge. She was seen as a writer and mathematician. The deity depicted as a woman often wore a panther skin a staff and a headband, over which a green star is depicted, which many researchers interpret as hemp bloom.The Ebers Papyrus is a medical script from Ancient Egypt. It is one of the oldest surviving texts and contains texts on medical topics with a wide range of descriptions of diseases and their symptoms and diagnoses. In addition, the papyrus contains tips for the treatment of various ailments and the preparation of remedies.The uses of cannabis for medical purposes recorded there date from 1700 BC. Various texts describe the application and preparation of several cannabis recipes. Thus, tinctures of cannabis and other herbs and plants to help with glaucoma, relieve nail problems or help in the form of vaginal suppositories from cannabis and honey at birth. Also in the coffins of mummies researchers found remains of the hemp plant, which were given to the person as an important tool on the journey.Cannabis from EgyptWhen Napoleon besieged Egypt during the Egyptian expedition from 1798 to 1801, French soldiers came into contact with hashish. It is believed that they took the hashish to Europe, which made it well known and appreciated.Although cannabis is illegal in Egypt and consumption and cultivation are severely punished, the historical significance and use of beneficial and medicinal plants suggest that hemp has played an important role in ancient Egypt. Perhaps the increasing research into medicinal properties can help bring hemp back to the center of society.Source: BOEDEFELD, Christian. CBD (Cannabidiol) im alten Ägypten.28 Mai, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabismedizin-allgemein/cbd-cannabidiol-im-alten-aegypten/ Source photo: https://pixabay.com/cs/   

Can cannabis protect the liver from alcohol damage?

This is a medical recommendation for the use of alcohol. By regularly exceeding this daily dose serious health consequences are threatened because alcohol is toxic to the liver cells. Excessive consumption causes the liver to become inflamed, tissue scarred, and dangerous cirrhosis can be the result, as well as high blood pressure, strokes, liver disease and liver cancer.Is the combination of alcohol and cannabis more dangerous than the individual substances?Recently, scientists from the University of Massachusetts Medical School and the INRS Armand-Frappier Research Center, led by Drs. Terence Bukong on the effects of long-term mixed cannabis and alcohol use on the liver. The 2018 study included studies in about 320,000 people who had a longer history of both substances. And although one would think that combined consumption would necessarily increase the negative consequences for the body, the results of the investigations show that it is surprisingly different in this case.Cannabinoids like CBD inhibit the cause of liver diseaseBukong and his team found that in people who consume both alcohol and cannabis, the risk of alcohol-related liver disease is lower. And the more cannabis people consume, the stronger this effect is. The researchers explain these amazing results with the anti-inflammatory effect that cannabis, and especially cannabidiol (CBD) has. Older studies suggest that cannabinoid receptors in the liver are able to prevent or treat liver disease. The activation of these receptors by cannabis reduces the inflammation of the liver cells at an early stage. This slows down the progressive damage caused by alcohol.The research on the mixed consumption of alcohol and cannabis goes into the next roundDr. However, Bukong warns against understanding the research findings as an invitation to excessive mixed drinking. Because many historical data were collected through interviews, there is no information on the quality and drug concentration of cannabis that the participants consumed at that time. So far, there are no clinical studies that have tracked the effects of mixed consumption virtually in real time. Bukong's research group is already working to find out which cannabinoids and combinations of cannabinoids have the best medical effect on liver disease.Coffee and cannabis prevent scarring in liver tissueDespite all precaution and caution, as a result of their research, researchers find that cannabis users are less likely to suffer from alcohol-related liver damage, the least to long-term consumers. Also good for preventing scarring in the tissues of the liver should be drinking two to three cups of black coffee per day. Why this is so, has not been explored until today. Source:KLAUS GLASMANN, Dieter. Kann Cannabis die Leber vor Alkohol-Schäden schützen? 28 Mai, 2019. Dostupné z: https://www.hanf-magazin.com/medizin/cannabismedizin-allgemein/kann-cannabis-die-leber-vor-alkohol-schaden-schuetzen/Source photo: https://pixabay.com/cs/