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CBD and the Immune System - Can Cannabidiol Support the Immune System?

Colds, herpes, allergies - many complaints in everyday life, we lead back to the fact that our immune system does not work optimally. Sometimes it seems to let us down, sometimes it reacts stronger than it should. As scientific studies show, CBD could interfere with oil regulation: How does our immune system work?Our organism comes into daily contact with bacteria, viruses and environmental toxins. If foreign cells enter the body, we need an instance that distinguishes friend from enemy. This task is done by the human immune system. It's not a conduit network like our bloodstream and our nerve cells, but rather a communication network that involves cells of different types. They provide each other with information about potentially threatening substances and the state of health of tissues and organs. If a substance enters the system that is identified as hostile, certain signal substances (cytokines) initially trigger an inflammatory process. This alerts other immune cells, such as our leukocytes or killer cells. They have the ability to destroy and consume pathogens. Even infected body cells are destroyed by the defense cells. As efficient as it sounds - the human immune system is not always working optimally. Allergies arise when the immune system overreacts to certain plant substances. In contrast, autoimmune diseases develop when defense cells falsely attack their own body cells. Immune system and cannabinoids - where is the connection?Receptors, so "docking" for cannabinoids are located on many cells of the immune system. T cells, neutrophil granocytes, monocytes, NK cells and B cells have CB2 receptors to which cannabinoids can bind. If they do so, they attract other immune cells to a damaged site in the organism through chemical signals. At the same time, however, cannabinoids are also responsible for balancing the immune system and avoiding overreactions. This task is usually done by our endogenous cannabinoids, the endocannabinoids. However, if there are deficits or imbalances, herbal cannabinoids such as CBD can be helpful. The optimal function of our immune system depends directly on the balance of our endocannabinoid system. If the CB1 receptors in our body are strongly inhibited, the immune system may be impaired in its function. If the organism does not have endocannabinoids such as anandamide and 2-AG, it may lead to diseases such as irritable bowel, fibromyalgia or migraine. Scientists believe that supplementing herbal cannabinoids in these cases can promote good health. Source: CBD und das Immunsystem – kann Cannabidiol die Immunabwehr unterstützen? Apr 29,2019. Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-und-das-immunsystem Source photo: https://pixabay.com/cs/

CBD in allergies - can cannabidiol soothe the immune system?

Some of them are happy when trees and flowers are blooming in spring, while others would rather escape to the North Pole. In particular, hay fever sufferers can hardly enjoy the warm season, because they bring along with the pollen Schniefnasen, watery eyes and sneezing attacks. But also food allergies; House dust allergies and incompatibilities with chemicals make everyday life difficult for those affected. What happens in the body during allergies, such as CBD oil could increase the well-being of allergy sufferers, you will find out here: What are allergies?In an allergy, the human organism reacts to individual substances of its environment (allergens) with a strong immune response. In this case, pro-inflammatory substances such as e.g. Released histamine that cause typical discomfort. The physical symptoms then express themselves in:red and irritated eyesirritated nasal mucosahay feverSneezeto coughallergic asthmadigestive problemsSkin irritation and rashEczema and eczemaFor example, allergens are taken via the respiratory tract, as is the case with widespread hay fever. According to recent surveys, about 14.5 percent of all Germans suffer from respiratory ailments during their heyday. In addition, allergens can also enter the body through food or through direct skin contact. What is the usual therapy for allergies?Here are two approaches: The first is based on drugs that reduce the production of the inflammatory histamine in the body, so-called antihistamines. These preparations are effective and are available over the counter. However, they are sometimes associated with unpleasant side effects, especially with severe fatigue. In addition, there is the possibility of hyposensitization for allergy sufferers. In this case, the person concerned receives low-dose injections of the corresponding allergen, in order to slowly get the body used to the substance. How does CBD affect our immune system? The human endocannabinoid system and the immune system are closely related. After all, CB2 receptors to which cannabinode can bind are located on the important cells of the immune system, for example the T cells. Here, cannabinoids can regulate how many pro-inflammatory signaling substances are released during an immune response. Researchers in the animal model of asthma demonstrated that this regulatory effect can have a beneficial effect on allergic reactions. Treatment with CBD was able to significantly reduce the pro-inflammatory signaling, various interleukins and tumor necrosis factor alpha in the lung tissue of the experimental animals. The authors of the study are in favor of CBD as a potential future therapeutic for the inflammatory processes in asthma. Surveys in dermatology, however, see opportunities in CBD to treat atopic dermatitis and contact allergies. Finally, scientists in the animal model of arthritis have observed that cannabidiol can also regulate autoimmune responses by reducing the presence of proinflammatory signaling in the synovial fluid.  Which CBD products are suitable for an allergy?Dietary supplements with CBD are freely available in Germany and do not bring the risk of side effects. Unlike with the use of antihistamines, allergy sufferers do not have to worry about drowsiness. It is known from scientific experiments that CBD is absorbed well via the oral mucosa and via the transdermal route. In principle, allergy sufferers can therefore use CBD oil or CBD balm. When products are applied to the skin, it is important that there are no ingredients that can cause allergies. Ideal are CBD balms, which contain only natural fats such as shea butter or mango butter and do without chemical preservatives and fragrances. Even less risk of allergies exists in CBD oils based on MCT oils. They are dripped under the tongue on the oral mucosa to ensure optimal absorption of the ingredients in the organism. Beginners should begin with a 5 to 10 percent CBD oil picking and a dosage of 3 drops twice a day. Source: CBD bei Allergien – kann Cannabidiol das Immunsystem beruhigen?  May 2, 2019. Dostupné z: https://fivebloom.de/blogs/cbd-news/cbd-bei-allergien-oder-heuschnupfen Source photo: https://pixabay.com/cs/

Does CBD help stomach and intestines? Cannabidiol and the digestive tract

A good gut feeling is not only important in the figurative sense: The fact that the digestive tract works smoothly is essential for general well-being. But there is a problem here: it is estimated that 29 percent of the European population experience recurring indigestion; A total of 400,000 patients in Germany suffer from inflammatory bowel disease. Could CBD oil help alleviate the symptoms here? Below you will learn how the endocannabinoid system interacts with the digestive tract and what recent studies on CBD have found in bowel disease: What makes a healthy digestive system?The health of our intestinal tract is not only our business, but also that of trillions of microorganisms. Their job is to help digestion, neutralize potential toxins, make vitamins and communicate with the immune system. If bacterial colonization in the intestine is disturbed by pathological conditions, chronic intestinal inflammation and even mental illness can be the result. Animal experiments have already shown how the change in the intestinal flora in mice results in increased anxiety and a tendency to depression. Also in patients with a post-traumatic stress disorder, changes were detected in the occurrence of special intestinal bacteria. No wonder then that our intestinal tract is also referred to by some scientists as the "gut brain". A gut feeling would therefore not be a vague feeling, but may be the result of the collective intelligence of trillions of intestinal bacteria. How do cannabinoids affect the intestine?The human endocannabinoid system also extends to our digestive organs. CB1 receptors are located in the stomach and intestine, where they allow (endo) cannabinoids to control appetite and saturation. In addition, they affect motility, i. the movements that maneuver our food through the digestive tract. Finally, the anti-inflammatory potential of some cannabinoids could have a positive effect on the intestinal mucosa and correlate with a healthy intestinal flora: In which intestinal diseases could CBD support well-being?A well-known chronic intestinal disease is irritable bowel syndrome. Physicians are still uncertain about his cause - but his symptoms severely affect the quality of life of those affected: diarrhea, flatulence, cramps and constipation are the result. Stress, intolerance to certain foods or taking hormone supplements such as the "pill" can cause relapses. Scientists are currently working on a theory that explains chronic pain in irritable bowel syndrome, which can hardly be attributed to external factors, by a lack of endocannabinoids (Clinical Endocannabinoid Deficiency Syndrome). [2] Here, an intake of herbal cannabinoids such as CBD could possibly have a positive effect and reduce painful discomfort. This thesis is supported by numerous reports of irritable bowel patients, whose quality of life CBD could increase. CBD and inflammatory bowel disease and CBDIn inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, there are inflammations of the intestinal tract, which cause bumpy severe discomfort. Doctors suspect the triggers in an autoimmune reaction. The fact that cannabis preparations can alleviate the symptoms is well known. [3] In addition, a 2011 study examined the mechanisms by which CBD, as a single substance, could exert a positive influence on inflammatory processes in the gut: it has been shown to control the activation of enteric glial cells. In turn, these cells increasingly release growth factors and inflammatory signaling substances (cytokines). In excess they can cause inflammation. The modulating capabilities of CBD could mitigate these processes.  Source: Hilft CBD Magen und Darm? Cannabidiol und der Verdauungstrakt. Apr,22 2019. Dostupné z: https://fivebloom.de/blogs/cbd-news/hilft-cbd-magen-und-darm Source photo: https://pixabay.com/cs/

Regular pain: CBD helps

CBD relaxes and relieves crampsWhile most of the average 28-day cycle is relatively calm and normal, the uterine muscles begin to contract just before the menstrual period. These contractions interrupt blood flow in the abdomen. It is precisely this interruption that causes more pain in one woman and less pain in the other. Happy are those who do not suffer at all. In some girls and women, however, the pain is so unbearable that they therefore even fail in everyday life, so must report to the employer sick or can not go to sports. In Germany, therefore, many patients resort to analgesics such as ibuprofen or acetaminophen. Others prefer to take antispasmodic drugs from the pharmacy. However, this is more of a permanent solution with two eyes closed, as this type of medication has negative effects on the body. For example, they strain the kidneys when taken regularly. Some pain sufferers now stick electrodes instead to the skin. By light surges, the muscles should relax and provide relief. While some swear by it, others complain about the annoying feeling of having to walk around the bikini area with electrode stickers, where one can not move quite as freely during the days anyway. Often, young women are prescribed the pill to prevent the unpleasant side effects of menstruation. However, it is artificially intervened in the hormone balance to prevent ovulation. The cannabinoid CBD is according to the current state of research free of side effects. It naturally acts on the human endocannabinoid system. This expands throughout the body and even produces various cannabinoids to keep the immune system intact. However, this system is prone to disorders such as illness and stress - the latter is also caused by pain. By administering CBD in the form of oil or capsules, the inner balance can be restored. CBD has a relaxing, anti-spasmodic and anti-inflammatory effect. For menstrual problems, it is therefore a good treatment option. Since it contains virtually no THC and therefore does not have an intoxicating effect, women who suffer from period pain can obtain CBD legally and without a prescription. Different types of menstrual pain and their causes The female cycle is determined by different hormones. The goal is to prepare the body for possible reproduction. Therefore, the uterine lining builds up in the first half of the cycle. It is well supplied with blood and thick or short: ready for the implantation of the fertilized egg. However, if there is no fertilization and thus no pregnancy, the mucosa dissolves in the second half of the cycle after ovulation from the uterus. The excretion takes place during the period. After the menstrual period, the circulation starts again, so the menstrual pain occurs every month again. Generally, a distinction is made between primary and secondary menstrual pain. The primary menstrual pain falls into the category of "natural", which is pain that occurs during the menstrual period, without any pathological change in the female body. The women who suffer from primary periodic pain have been fighting this problem since puberty. Secondary menstrual pain primarily affects older women and is mostly due to illness. Changes in the female reproductive system often cause painful days. Such changes include, for example, endometriosis (small, benign growths in the abdomen), uterine infections, and ovarian cysts. Frequently by these diseases not only the intensity of bleeding increases, but also pain. In general, there are various factors, besides malformations or diseases, which can aggravate menstrual pain. These include a low body weight, an irregular or longer than average cycle, the consumption of alcohol and nicotine, the prevention of pregnancy with the help of the spiral, stress or other psychological causes. Symptoms of menstrual painMany readers know her too well - the typical symptoms of menstrual cramps: cramping and tearing in the abdomen. The pain can follow at short intervals, be regular or prolonged, and can be up to the back. Often, digestion is also affected during the period, so some women suffer from diarrhea or nausea. Even headaches can be part of the discomfort. Anyone who is in constant pain and uncomfortable will eventually get into a bad mood. In addition, fatigue, fatigue and lower concentration or performance are added to this. Many women would therefore just like to lie in the hot tub or with a hot water bottle on the stomach on the couch and wait for the first two, so the worst days, pass as quickly as possible. Different forms of CBD for menstrual pain Not only hot baths and hot water bottles relax the cramped uterus, but also sex. But after a suitable partner is not always and everywhere available and women can not spend hours in the bathroom, it makes sense to relax the body in other ways. CBD has anti-spasmodic properties, reduces stress and relaxes, and therefore relieves menstrual pain. Already Queen Victoria's doctor, Sir Joshua Reynolds, knew about the beneficial effects of the cannabis plant and ordered the majesty a suitable cannabis tincture against her menstrual pain. Women in Asia and Africa have also been relying on natural pain relief from cannabis products for centuries. In our society, the use and research of cannabinoids has long been neglected by the illegalization of the hemp plant. However, countries such as the US and Canada are now turning around and the research and production of various cannabis products is evidently progressing inexorably. Europe is slowly catching up. The US actress Whoopi Goldberg has recognized the trend and together with the food manufacturer Maya Elisabeth sells medical cannabis products under the name "whoopi & maya", which are tailored to women with regular pains. In addition to cannabis tinctures and ointments, the ladies also offer a bath additive and chocolate with the corresponding active ingredients. In liberal California and the US state of Colorado, pain-stricken women enjoy the so-called cannabis tampons, which are marketed under the name of Foria Relief. Actually, this product is not really a tampon, but a suppository, which is introduced before using a tampon. Within 15 to 30 minutes, the suppository dissolves, so that the active ingredients are absorbed by the vaginal mucosa. In Germany, the suppositories are not yet available because they contain besides ten milligrams of legal CBD also 60 milligrams of psychoactive THC. Many women reported having a relaxing effect and pain relief after about eight minutes. The THC can be detected by the usual drug tests in the body. Medically sound studies on Foria Relief are pending. We also have medical cannabis products on prescription from the pharmacy. These are mainly used in palliative medicine. In menstrual pain, it would be extremely difficult to find a doctor and a health insurance company who would participate in a prescription. The legal alternative is CBD. In the form of oil, you can either take cannabidiol orally or drip one or two drops on a tampon to make it easier to get it right where it's needed. Instructions for buying CBD productsTo minimize the unwanted ingestion of any pollutants, attention should be paid to the bio-seal when purchasing CBD products. Oils should contain at least 99 percent pure CBD. When manufacturing, it is important to keep an eye on ensuring that the products are as close as possible to the GMP (Good Manufacturing Practice for Medicines) and ISO standards so that they are of a certain quality. Court decision regarding cannabis use against menstrual painAt this point the readers should not be deprived of the court order of 4 January 2017 from Baden-Württemberg: A woman who regularly consumed cannabis for six to seven days a month - the intoxicating THC variant, not the pure CBD - wanted to deprive the driving license authority of their driving license. In an urgent procedure, however, the Freiburg administrative court ruled that the woman was allowed to keep her driver's license for the time being. The reasoning was that the person concerned would firstly have not combined consumption and driving, and secondly, they would not take cannabis regularly. Even if the consumption was monthly over several days, the woman did not take THC-containing products on the menstruation-free days and therefore did not fulfill the conditions necessary for a driving license withdrawal.The decision may be understood as a positive sign in the direction of cannabis for pain relief. Source: SOMMER, Kathryn. Regelschmerzen: CBD schafft Abhilfe. 21 Feb, 2018 Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/regelschmerzen-cbd-schafft-abhilfe/ Source photo: https://pixabay.com/cs/

The function of endocannabinoids

Endogenous cannabinoids are produced in the body. Also exogenous phytocannabinoids from the cannabis plant or synthetic cannabinoids from the laboratory can be supplied to the body from the outside. These exogenous cannabinoids attach to the cannabinoid receptors and thus have an effect. First of all, this is about the function of endocannabinoids in our body, though the subject could certainly fill a book. In our body, thousands or even more functions take place side by side at the same time. There are organs in the body, but there are also small organs in many cells that perform functions. All this needs to be controlled so that it does not become "too little" or "too much". Simplified, it can be said that endocannabinoids in the organism take over a very important part of these "control functions" and that we thus find a "healthy center". This applies, on the one hand, to unconscious biochemical processes with which, for example, the feeling of hunger or sleep can be controlled. Of course, we realize that we are getting hungry or sleepy and react to these important impulses. But even with the feeling of pain, anxiety, aggression or mood, endocannabinoids bring us back to the center. Endocannabinoids than the other neurotransmittersThere is an incredible abundance of chemical substances in every higher organism, all of which have their functions. Neurotransmitters are messengers. A nerve cell releases them to trigger a reaction in another nerve cell. When a nerve cell perceives something or takes damage, it releases the appropriate neurotransmitter, which then triggers the impulse in the next nerve cell to pass on the information. Thus, information about the nerve tracts from the little toe can penetrate into the brain with almost no loss of time. Normal neurotransmitters are formed and released as needed. Endocannabinoids are formed as needed and distributed at the same time. Excessive impulses can not only drive pain patients to madness. Pain, just like anxiety or stress, is something very positive at first because it alerts the organism. After all, this must act quickly and quickly notice the problem. However, if too much pain, anxiety or stress, the organism can no longer follow the right actions on the impulse. Those who simply freeze in fear, respond to a dangerous moment usually not right. Because of the endocannabinoids, cannabinoid receptors have the property of not only relaying the message from the impulse. You can also answer the impulse. So you can soothe the "source of stimulation", so that the over-stimulation fails and the organism can react more meaningful to the impulse. Endocannabinoids are therefore very important messengers, with which body functions or sensations take place, but no excess occurs. Endocannabinoids in healthIn health, "mediocrity" is, as it were, the prerequisite for being healthy and staying healthy. Much just wants to be detrimental to a defect or excess and is not questionable. This applies when eating, e.g. for fat, without it just being not. So it has to be a certain amount of fat, which composition should bring a certain quality for the body. Polyunsaturated fatty acids are much healthier than the saturated fatty acids. Too much fat is unhealthy at some point, too little too. Many illnesses come from a "too little" or "too much". If the endocannabinoid system is disturbed and too few endocannabinoids are formed, they can bring the organism less well into the healthy center. Many diseases are due to search "imbalances" in the endocannabinoid system or cause search "imbalances". Here it can help if the right exogenous cannabinoids are added to the endocannabinoid system. There are also special living conditions. A painful back pain or a part of the body has been operated on and hurts since then. It can therefore be about traumatizing events. The actual healthy person takes damage over time, where his actually healthy endocannabinoid system does not lead to the middle anymore. Again, it may help if the right exogenous cannabinoids are supplied. Physical or mental pain can be reduced. Effects of EndocannabinoidsThe areas of action of the endocannabinoids actually comprise the entirety of the unconscious and the conscious bodily functions. Whether it is about mood, metabolism, digestion, appetite, sleeping, pain, the elimination of inflammation, immune functions or memory: without endocannabinoids, the organism can not find the mediocrity. Endocannabinoids are somewhat superior to the exogenous cannabinoids in that they are released in the right places in the body. So they are work in the right places. If exogenous cannabinoids are added, they are absorbed into the bloodstream via the digestive system, the lung or under the tongue. In this way, they reach the whole organism and therefore affect the whole organism. In some situations this can be detrimental. Source: BRUNGERT, Robert. Die Funktion der Endocannabinoide17 Feb, 2018,Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/die-funktion-der-endocannabinoide/ Source photo: https://pixabay.com/cs/

The endocannabinoid system: How THC works in the body

The beginningsModern cannabinoid research, which began about 50 years ago, was initially initiated to understand the effect of an illicit drug. After the chemistry of the plant and the pharmacological and psychological effects of THC were at least partially understood in the 60s and 70s, the field of research changed. From the mid-80s, research into the mode of action of THC and other cannabinoids in the hemp plant in the body and thus the discovery of the endocannabinoid system began. It soon became clear that this body's regulatory system is involved in many bodily functions.In 1964, the complete elucidation of the chemical structure of the delta-9-THC of the hemp plant was achieved. Approximately 30 years later, the first endogenous cannabinoids were discovered, arachidonoylethanolamide (anandamide, AEA) in 1992, and arachidonoylglycerol (2-AG) in 1995. Since then, research on the effects of endocannabinoids on human health and disease has become more widespread.Endocannabinoid receptorsIn 1987, an American research group was able to show that there are specific binding sites in the brain for THC. Their distribution in the brain is consistent with the pharmacological properties of THC and other (synthetic) cannabinoids that cause psychic effects. In 1990, it was finally possible to decode the chemical structure of the first cannabinoid receptor in the brain. A short time later, a second cannabinoid receptor was detected in the spleen.The cannabinoid-1 receptorOriginally it had been thought that the CB1 receptor (cannabinoid-1 receptor) was found only in the central nervous system, so it was considered a brain cannabinoid receptor. However, it occurs in many organs. The CB1 receptor is one of the most common receptors in the brain. The highest concentrations are found, among others, in the basal ganglia of the brain, which play a role in the coordination of movements, or in the hippocampus, which is important for the conversion of short-term information into long-term memory contents or for spatial orientation. CB1 receptors are found in many regions that play an important role in sensory perception (taste, smell, touch, hearing), mental performance, and motivation. For example, when CB1 receptors in the brain are activated by THC, sensory perception increases. In this way, the taste and smell of food and listening to music intensifies.In contrast, there are no CB1 receptors in the brainstem responsible, inter alia, for the control of respiration and the cardiovascular system. Today it is assumed that there are no deaths from overdose of cannabis or THC in healthy persons, because the functions of the brainstem can not be significantly affected by such an overdose.The protective function of the CB1 receptorCannabinoid 1 receptors are located at the end of nerve cells, where a signal is passed through the gap between two nerve cells from one nerve cell to another. The most important function of the CB1 receptors in the nervous system is the inhibition of excessive signal transmission by messenger substances in the brain, so-called neurotransmitters. Activation of CB1 receptors inhibits overactivity of all neurotransmitters in the brain (glutamate, serotonin, dopamine, norepinephrine, etc.). Thus, the endocannabinoid system has multiple protective functions against over-excitement in the central nervous system and helps to balance the activity of the brain. This explains the broad spectrum of action of THC or cannabis. When THC binds to CB1 receptors, too much activity is inhibited in the pain control circuits of the brain, thereby relieving pain. If neurotransmitter activity is too high in regions responsible for nausea and vomiting, activation of the CB1 receptor may reduce this increased activity. By similar mechanisms, muscle spasticity, epileptic seizures, anxiety disorders, obsessive-compulsive disorder, hyperactivity and other disease symptoms are attenuated by activation of the endocannabinoid system.The cannabinoid 2 receptorOriginally it was thought that CB2 receptors only occur in the immune system outside the brain. However, they were eventually detected throughout the central nervous system, especially in microglial cells, albeit at a lower concentration than CB1 receptors. Microglial cells are crucial for brain immune defense.The body of humans and other mammals has a highly developed immune system that protects it from attack by viruses, bacteria and other potentially harmful external influences and aims to prevent, mitigate and repair the damage. The endocannabinoid system is part of this protective mechanism via its CB2 receptors.Endogenous cannabinoidsThe discovery of cannabinoid receptors suggested that there are endogenous substances that bind to these receptors. In fact, such an endocannabinoid was first detected in 1992. Its discoverers called it anandamide from the Sanskrit word "Ananda" for bliss and "amide" because of its chemical structure. In 1995, a second endocannabinoid, 2-AG (2-arachidonoylglycerol) was discovered. These two endocannabinoids are best researched so far. Today it is assumed that about 200 substances that resemble the discovered endocannabinoids in their chemical structure.Unlike most messenger substances (neurotransmitters) in the brain, they are not produced by the nerve cell, which transmits a signal to another nerve cell, but by the nerve cell that receives the signal. If the signal, ie the concentration of the neurotransmitters, is too large, endocannabinoids are increasingly formed which, via the activation of CB1 receptors, reduce this excessive neurotransmitter activity.Different endocannabinoids can bind not only to cannabinoid receptors, but also to a putative CB3 receptor, the GPR55 receptor, vanilloid receptors, and other receptors.Proteins for the formation and degradation of end cannabinoidsThe proteins responsible for the synthesis of endocannabinoids have so-called N-acyltransferase (NAT), N-acylphosphatidylethanolamine-specific phospholipase (NAPE-PLD) or diaclglycirollipase (DAGL). The most important protein for the degradation of anandamide is fatty acid amide hydrolase (FAAH) and for the degradation of 2-AG monoacylglycerol lipase (MAGL).Functions of the endocannabinoid system in the brainThe endocannabinoid system plays a role in the brain in anxiety and depression, in the regeneration of nerve cells, and it affects the reward system of the brain. It affects our mental capacity, ability to learn and memory. In this context, the eradication of unpleasant experiences by the endocannabinoid system is utilized in the treatment of post-traumatic stress disorder. The effects of endocannabinoids in the brain are mainly mediated via CB1 receptors, but also in part via CB2 receptors on glial cells.Many studies show that activators of the CB1 receptor, such as THC, affect short-term memory. This effect can be prevented by high doses of CBD.Interestingly, however, memory loss could be reduced with age by activating the endocannabinoid system. For example, mice lacking CB1 receptors showed accelerated age-related mental performance deficits. They also lost important nerve cells in the hippocampus, which was accompanied by inflammation of the nerve cells. These findings suggest that CB1 receptors in the hippocampus may protect against age-related decline in mental performance.conclusionThe endocannabinoid system, with its endocannabinoids, cannabinoid receptors, and proteins responsible for the formation and degradation of endocannabinoids such as anandamide and 2-AG, has central biological functions in the central nervous system and in many other organs. Disruptions to the normal functioning of this system can lead to corresponding disorders of organ function. In diseases, a specific effect on the endocannabinoid system may be useful, for example, by inhibiting the degradation of endocannabinoids or by the administration of herbal cannabinoids such as THC.There is also evidence that certain diseases such as migraine, epilepsy or irritable bowel syndrome are associated with reduced activity of the endocannabinoid system. One speaks of Endocannabinoidmangel illnesses. The ingestion of plant cannabinoids might then compensate for this decreased activity. Source: GROTENHERMEN, Dr. Franjo. Das Endocannabinoidsystem: Wie THC seine Wirkung im Körper ausübt.15 Aug, 2016,Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/thc/das-endocannabinoidsystem-wie-thc-seine-wirkung-im-koerper-ausuebt Source photo: https://pixabay.com/cs/