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Endogenous cannabinoids

Our organism, a criminal?The production of cannabis or the intoxicating tetrahydrocannabinol is prohibited in Germany, with exceptions. Our body forms endogenous cannabinoids. The anandamide discovered in 1992 is very similar to the THC. Is our organism a criminal? Does the mother behave irresponsibly when giving birth to her child, although breast milk contains endogenous cannabinoids? These questions simply remain unanswered and continue to focus on endogenous cannabinoids. Every higher living organism has an endocannabinoid system in which there are endogenous cannabinoids and cannabinoid receptors. These cannabinoid receptors can also dock with exogenous cannabinoids that are formed outside the body. However, cannabinoids formed in the body are called "endogenous". Endogenous is used within, exogenously outside of the body and as terms also in other areas of medicine. In 1992, the first endogenous cannabinoid was discovered with "anandamide", meanwhile also "2-arachidonylglycerol", "2-arachidonylglyceryl ether" and "O-arachidonylethanolamide" were discovered. There may be dozens of other endogenous cannabinoids that our body produces itself. These are messengers that dock to the cannabinoid receptors and trigger a reaction. Exogenous and endogenous cannabinoidsAmong the exogenous cannabinoids there are once the phytocannabinoids and the synthetic or semi-synthetic / artificial cannabinoids. The endogenous cannabinoids are always natural products as a product within our body. Here, however, as an organism, there are no great possibilities to form less or more of these endogenous cannabinoids, e.g. to achieve a more pleasant way of working. In the case of exogenous cannabinoids, however, it is possible to take them in any amount, if they are available in any quantity. Since marijuana always contains several cannabinoids at the same time, it would hardly be possible for normal users to take more of one cannabinoid without also including the other contained cannabinoids. However, if today's world wants it, then all of this would be possible because the cannabis strains can be optimized for breeding goals. On the other hand, the active ingredients can be extracted from the flowers as pure substances and then dosed very precisely. The difference in the bodyWhen exogenous cannabinoids are taken, they are taken up by the body via the lungs, the intestine, or the mucous membranes and pass into the bloodstream. This reaches the whole body and thus the effect of the exogenous cannabinoids also unfolds throughout the body. An exception would be only the external application of skin disorders. Endogenous cannabinoids, on the other hand, are always released where they are supposed to work. In the same body region where these agents or messengers arise, there are the matching cannabinoid receptors. As long as there are no messenger substances or they do not dock, the reaction of the receptors will be off, so they are so long inactive. However, if they are to react, the messenger substances are released to trigger a very targeted and spatially limited response. Delta-9-THC and anandamide are very similar in their effect. This THC is the only phytocannabinoid, which has an intoxicating effect and triggers the high. If anandamide is released in the organism, then only regionally. However, if you were to administer anandamide from the outside, it would go through the blood in the whole body and would certainly also make high. The name Anandamid was after all derived from Ananda, which means "bliss" and comes from the Sanskrit. Nevertheless, it can develop a very good medical effect in various diseases when THC is supplied to the organism. For the medical effect often enough dosages that do not make high, so that an everyday life remains possible. Difference between healthy and sickIn a healthy person, enough endogenous cannabinoids are released in different situations for the body to function normally. After all, cannabinoids are crucially important as messengers in the cannabinoid system, in order to control many different conscious and unconscious functions. In a sick person, there may be a deficiency in this cannabinoid system either at one or in some places. However, there may also be an additional need due to the disease. In both situations, it makes sense to take the right exogenous cannabinoids in sufficient quantities. In addition, of course, also be teased for pleasure. Or you simply take precautionary or relaxation CBD as well as other non-intoxicating cannabinoids. The healthy person can not do so much wrong, or would then usually stop by themselves quickly. In sick people, however, the difference in the effect is greater, which cannabinoids are taken in which concentration. Individual cannabinoids can be counterproductive in some diseases. Thus, too much THC can aggravate psychotic disorders quickly, but very often can be treated very well with CBD. While one can not exert much influence on the endogenous cannabinoids, as they are secreted by themselves in the body, exogenous cannabinoids can be used to great effect. That's exactly where the chances are in cannabinoid medicine. Source: BRUNGERT, Robert. Endogene Cannabinoide, 7 march 2018. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/endogene-cannabinoide/ Source photo: https://pixabay.com/cs/ 

What is cannabidiol?

Cannabidiol (abbreviated: CBD) is the second most abundant cannabinoid in hemp, after the main active ingredient THC. It therefore belongs to the phytocannabinoids and occurs mainly in the hemp with an amount of up to 2% in the flowers.Cannabis indica-dominant strains have a higher CBD content than strains dominated by cannabis sativa.CBD taken alone does not cause any intoxication - it is not essentially psychotropic (with the exception of the slightly sedating effect) - and no relevant (psychic) ​​side effects.The individual effects of the substance, as well as those of other cannabinoids, have not been fully explored. So there is room for discovery of other medical effects. The effect in isolated form is also to be considered differently than in combination with many other substances of the cannabis plant (for example over 100 cannabinoids alone, as well as flavonoids, terpenes, terpenoids).CBD mediates its effects via both the CB1 and CB2 receptors. These are receptors of the endocannabinoid system (ECS), are activated or inhibited by the body's own cannabinoids (endocannabinoids) and influence many physiological processes; Among other things, the EC system has an involvement in diseases of the metabolism, disorders of the nervous system and the psyche, pain and inflammatory processes, cancers and diseases of the gastrointestinal tract, to name just a few examples.CBD can be understood as mediating the effects of THC, as it enhances the analgesic, mind-altering and euphoric properties of THC; On the other hand, it acts as an antagonist by inhibiting the increase in appetite caused by THC, increasing the heart rate as well as any unpleasant psychological effects (increased anxiety, anxiety, paranoia).For a long time, cannabis breeders were primarily concerned with keeping the CBD content as low as possible in order to achieve a better "high". So it is in many popular cannabis strains at less than one percent. Meanwhile, however, there is a clear trend of medical use in the direction of high-CBD strains, so CBD-rich varieties, which come up with a significant medical potential, without really psychedelic effect.The effect here is more towards plättend, body-accentuated and pleasantly soothing on the psyche. Therefore, CBD-rich cannabis strains (e.g., in ratio (CBD-THC) 1: 1 or even 2: 1) are ideally suited for treatment of, for example, muscle spasms, sleep disorders, and anxiety.CBD is not regulated in Germany, Austria and Switzerland and is absolutely legal in its pure form. Source: FÖRSTER, Hendrik. Was ist Cannabidiol? 13 Jan, 2015. Dostupné z: https://www.hanf-magazin.com/medizin/cannabinoide/cbd-in-der-medizin/was-ist-cannabidiol/ Source photo: https://pixabay.com/cs/